Cartilage consists of cells called chondrocytes that generate substances that make up the
cartilage matrix, such as collagen fibres and proteoglycans (e.g. aggrecan). Data suggest that ASU may restore the structural components of the cartilage matrix as well as limit the inflammatory process
1. Based on results gathered from both in vivo and in vitro studies, several potential mechanisms have been proposed to describe the potential effects of
Avocado Soybean Unsaponifiable on osteoarthritis-affected joints, including inhibition of collagen breakdown, and stimulation of collagen and proteoglycan synthesis
2.
1. Kawcak CE, Frisbie DD, McIlwraith CW, Werpy NM, Park RD. Evaluation of avocado and soybean unsaponifiable extracts for treatment of horses with experimentally induced osteoarthritis. Am J Vet Res 2007;68:598 604.
2. Khayyal MT, el Ghazaly MA. The possible 'chondroprotective' effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp Clin Res 1998; 24: 41 50.
